Over the past twenty-five years, the emergence of DNA testing has changed the landscape of forensic science. While DNA testing is often used in criminal cases, it is estimated that 25% - 35% of all evidence samples submitted to crime laboratories fail to produce an informative DNA result with standard methods, frequently due to DNA degradation or low DNA quantity. Besides hampering investigations, these challenging samples frequently require labor-intensive re-processing before being abandoned, further increasing inefficiencies that contribute to increased costs, lengthy turnaround times, and casework backlogs.read more
Cancer is one of the leading causes of death globally. According to the World Health Organization, over 14 million new cancer cases were reported in 2012 and over 8 million people died worldwide. In the United States, cancer kills over 1600 people every day, and accounts for nearly 1 of every 4 deaths.
Effective cancer management depends on early diagnosis, accurate tumor staging, and consistent monitoring to prevent metastasis. However, many current diagnostic procedures are invasive, expensive and unpleasant. In multiple recent published studies, circulating cell-free DNA (cfDNA) concentration and integrity (fragmentation pattern), measured via high copy number retrotransposable elements (REs) of varying sizes, has shown promise as a highly accurate blood biomarker for multiple cancer typesread more